D.J.W. (Daniël Johannes Wilhelmus) Touw
PhD Track Data science for the public sector
This project focuses on developing and applying novel, non-parametric, methods to explore large data sets. In particular, we aim to develop methods that can be used both to summarize relationships and, if appropriate, predict relevant events. The focus will be on new, algorithmic approaches that require no distributional assumptions and their application to applications in the public sector.
Some specific problems often encountered in “big data” related prediction and exploration settings that are to be addressed in this study concern:
- Sample selection and balance problems (e.g., many prediction problems concern relatively “rare” events. In such cases, often non-random samples are taken and used as input for prediction models);
- Automated variable selection procedures (e.g., which variables, or combinations thereof, are relevant for predicting and/or understanding, certain events);
- Time dependence and dynamics of the problems (i.e., with quickly changing environments, models need to be updated frequently or even continuously. However, many advanced prediction methods are computationally intensive making it impossible to provide fast, and accurate, results);
- Interpretation of results. Machine learning methods place a heavy emphasis on prediction performance. Consequently, interpretation of the results is often not trivial. Applications in the public sector, however, can have far reaching societal impact. Therefore, understanding of the roles of leading indicators and/or underlying interactions, is of great importance.
- Keywords
- Big data, machine learning, unsupervised learning, supervised learning, dimension reduction, cluster analysis and least-squares methods.
- Time frame
- 2020 -
Publications
Article (3)
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Academic (3)
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the Dutch Pharmacology Oncology Group (DPOG) (2024). Sunitinib for the treatment of metastatic gastrointestinal stromal tumors: the effect of TDM-guided dose optimization on clinical outcomes. ESMO Open, 9(6), Article 103477. https://doi.org/10.1016/j.esmoop.2024.103477
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Vinke, J. S. J., Wouters, H. J. C. M., TransplantLines Investigators, Stam, S. P., Douwes, R. M., Post, A., Gomes-Neto, A. W., van der Klauw, M. M., Berger, S. P., Bakker, S. J. L., De Borst, M. H., & Eisenga, M. F. (2022). Decreased haemoglobin levels are associated with lower muscle mass and strength in kidney transplant recipients. Journal of Cachexia, Sarcopenia and Muscle, 13(4), 2044-2053. https://doi.org/10.1002/jcsm.12999
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Böhler, M., van den Berg, E. H., TransplantLines Investigators, Almanza, M. C. T., Connelly, M. A., Bakker, S. J. L., de Meijer, V. E., Dullaart, R. P. F., & Blokzijl, H. (2022). Branched chain amino acids are associated with metabolic complications in liver transplant recipients. Clinical Biochemistry, 102, 26-33. https://doi.org/10.1016/j.clinbiochem.2022.01.009
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Address
Burgemeester Oudlaan 50
3062 PA Rotterdam
Postbus 1738
3000 DR Rotterdam
Netherlands
Supervisory Team
